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Who are they?

"The Big Bang Theory" is centered on physicists Sheldon Cooper and Leonard Hofstadter, whose geeky and introverted lives are changed when Penny, an attractive waitress and aspiring actress, moves into the apartment across from theirs. Penny quickly becomes a part of Sheldon and Leonard's social group, which includes the equally geeky engineer Howard Wolowitz and astrophysicist Raj Koothrappali, with Penny's common sense and social skills and the guys' geeky interests expanding each other's worlds. The newest additions to the group are Howard's wife Bernadette Rostenkowski-Wolowitz and Sheldon's girlfriend Amy Farrah Fowler.

Source: TheBigBangTheory.com